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Supporting vegetarian and vegan diets with Lamberts Healthcare

In the coming years, it is expected that many will limit or completely cut their meat intake, with motives relating to animal welfare, personal wellbeing and environmental protection contributing to the popularity of both veganism and vegetarianism. Coupled with the fact that plant-based eating is observed across many different faith groups, it is unsurprising that many of us are now substituting our animal-based foods for plant-based alternatives, which can be equally as flavoursome and fulfilling to the palate.

Whilst both vegetarian and vegan diets confer many benefits, it is important to be mindful of the potential pitfalls. As with any diet that limits the intake of certain food groups, it is important to ensure that we are receiving the correct balance of nutrients through the foods we consume on a day-to-day basis. Supplementing the diet with a high-quality multivitamin and mineral formula can help to bridge some of the nutritional gaps for vegetarians and vegans alike.

Which formula is right for me?

With the Lamberts product range, there are no added barriers to obtaining the best nutrients for your health, with a large range of multivitamin and mineral formulas suitable for both vegetarians and vegans. Of course, it is always important to check the label to determine whether a specific multiple formula is suitable for vegetarians and/or vegans. Here at Dennis Gore Pharmacy, we have rounded up some of our top picks in the Lamberts Range for supporting vegan and vegetarian diets.

Our top picks

Multi-Guard® 

Frequently coined the ‘practitioner’s multi’, Lamberts Multi-Guard provides a comprehensive spectrum of nutrients at relevant potencies, with the addition of plant antioxidants. Suitable for vegan consumption, what sets this product aside is the inclusion of algal-origin vitamin D3. This source of vitamin D3 has exactly the same bioavailability as vitamin D3 from lanolin – the traditional source of vitamin D3, found in most multiple formulas. This formula includes relevant levels of vitamin B12 and D, iron and zinc. Research indicates that many plant-focused eaters would benefit from the consumption of these key nutrients, given they can be difficult to obtain without the inclusion of animal-based foods.

Florisene® 

Whilst an iron deficiency is certainly not exclusive to a vegetarian or vegan diet, ensuring a sufficient dietary intake is still fundamental. Florisene is a vegan formula that provides a highly absorbable form of iron alongside the essential amino acid, L-lysine. Research indicates that a low L-lysine intake may exacerbate a reduced ferritin level, and that for some women, ferritin levels will not improve without L-lysine. With rich sources of l-lysine including meat and poultry, vegans and vegetarians may struggle with their dietary intake of this amino acid, which is where a supplement can help.

FEMA45+™ 

Menopause can put a lot of demand on your body, increasing the likelihood of developing nutrient deficiencies. FEMA45+, suitable for vegetarians, has been formulated specially for women during and after the menopause, providing 28 nutrients at relevant levels, including the trace minerals and plenty of antioxidants. What sets FEMA45+ aside is that it provides excellent levels of magnesium and calcium, as well as vitamins D and K to reflect the current thinking on bone health.

Strong-Start MVM® 

Whilst a well-planned vegetarian diet can provide sufficient levels of the nutrients needed for pregnancy, the NHS states that it is important to be mindful of your vitamin B12 and D, iron and iodine intake if you’re pregnant and vegetarian. StrongStart MVM is a vegetarian formula that has been developed to support the nutritional requirements of women during preconception, pregnancy, and breastfeeding. Carefully formulated by experts in the field, StrongStart MVM provides all of the nutrients above, alongside 400µg of folic acid which contributes to maternal tissue growth during pregnancy.

Multi-Guard® Control 

This vegetarian formula provides 25 nutrients, including 200µg of chromium, plus 300mg of magnesium since it is a component of many enzymes involved in the breakdown of blood sugar, and tends to be deficient in diets based on refined carbohydrates. This product also provides a concentrated extract of cinnamon which is included at a level that reflects the research carried out on this spice and its influence on blood sugar levels.

A to z

Suitable for vegetarians, A to Z is a broad-spectrum multivitamin that supplies the most important micronutrients at a minimum of 100% of the Nutrient Reference Value (NRV). This formula can be taken by all adult age groups and is best recommended as a good insurance policy for teenagers (13 years+) and young adults.

Conclusion

As we have seen, taking a multiple formula can be very helpful when ensuring that all nutritional bases are covered, especially when following a vegetarian or vegan diet. Given that certain groups of people share common micronutrient requirements, choosing the correct formula is key. Please contact a member of the team for further information on which formula is right for you, as well as information on the full range of Lamberts Multiple Formulas that we stock.

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Inside a Pharmacy during COVID 19

In the first week of March news from China and Italy about the COVID 19 SARS outbreak began to alarm me, we had already made some preparations such as purchasing contingency stock of PPE for the staff and increasing stock of relevant products but I knew I would have to take more critical steps to assure the safety of pharmacy staff if the COVID -19 SARS outbreak was to become a pandemic. It was 2009 that Swine flu threatened to become a pandemic, as a pharmacist back then we were educated by mandatory training organised by the NHS. I had some idea of what to expect. It was well known that as a result of official risk assessments that a full pandemic is the most highly disruptive event a nation can experience. After some quick measurements I rang up a local DIY merchant “Relionus, Prestwich” and ordered several cut sheets of perspex plexiglass. The day after the pandemic was called we had competed the installation of 2m high barrier. These barriers are now known as “cough and sneeze” barriers. At the same time against official government advice I requested all staff to donn gloves and face masks -that had been stockpiled- at all times during work.

I shared my experience with other colleagues across the country and soon they also were building the “cough and sneeze” barriers. Then the GPs surgeries began to operate a closed door policy. Hoards of people descended on community pharmacy for first response primary care. They wanted diagnosis, treatment and advice. We do offer this normally but only for the most minor of cases. The staff were panicked and I began to receive worrying emails from alerted staff. I sent one of those email to the BBC along with a short video of what i had done to prepare. We also saw a huge spike in prices of commodities and generic drugs. Many prices went over the official promised reimbursement price. In effect community pharmacy was paying for the Great British publics’ medicine. Of course we worried if we could afford this, just a 20 to 30% over-tariff spend would make a community pharmacy of any size in-effect bankrupt.

The email was picked up and in the height of the confusion, pre-lockdown Dominic Hughes (BBC) and his production team came and made an article for the national news.

Once the article was published we started to get very positive feedback from all over the world, including Ireland and Australia. Pharmacists in other countries began to install the simple “cough and sneeze” barriers. 2mm perspex and 2 x 1 inch wood baton for the framing.

Then the lock-down was called, all non essential businesses were to close including almost all retailers apart from Pharmacies and Supermarkets/ Grocers. The slow wheels of officialdom began to turn, each day new advice was issued to the public and healthcare workers on what to do. We called this official guidance.

At the start in early March official guidance said no masks needed, only use PPE to decontaminate a site when you have a confirmed case, no changes to your normal practice is needed. By the end of March now early April 2020 every retail pharmacy in the country will get £300.00 to erect social distancing barriers, they will also get a 25% advance cash payment to keep all pharmacies big and small solvent.

At the same time the local council has advised that all retail staff still in business must wear gloves and just today we are now told that in effect all staff must wear at least a surgical face mask and gloves in normal patient facing activity. The big problem here is that almost all personal protective equipment has now spiked in price and is not really affordable, what is available is highly likely to be fake or poor quality.

The take home lesson. Don’t wait for advice from above. Do your own research and act. 2-3 weeks after pandemic was called we are equipped and we are stocked.

Hand sanitiser is due in, vitamin c piled high, selenium, q10 immune boosters, ready and available.

We will deliver any NHS prescription free and deliver private pharmacy items such as medicines and personal care items at just a small fee of £3.00 for delivery.

https://www.bbc.co.uk/news/av/health-52008198/coronavirus-inside-a-community-pharmacy-under-pressure?fbclid=IwAR1wzymdrtxR8aht76_tdxg1ZqfGy5dEImn3oP36a4LBLJxUNJP9kmYK7bo

what is Co enzyme Q10?

How did the story of the oil-soluble, vitamin-like substance, Co enzyme Q10 start? Who were the major players involved in it’s discovery,knowledge of it’s properties,and new discoveries of it’s uses?

First, to remind us, what is it what is Co enzyme Q10?

Co enzyme Q10 is found in everyone of the little sausage-shaped bodies,(called the mitochondria), in the 100 trillion cells of which our body is made. There are between 500 and 3000 mitochondria in every cell! So in total that’s trillions and trillions of them in our body!

It is in these little engines that the food that we eat and the oxygen we breath, are used to produce our energy.

One of the main players,the “spark plug” in all this, is a natural substance called Co enzyme Q10,the job of which is to continually make and remake one of the the most famous molecules in medicine:- ADENOSINE TRIPLE PHOSPHATE (ATP).

This substance is continually being broken down to become ADENOSINE DOUBLE PHOSPHATE(ADP), the breaking down of which releases OUR ENERGY, only to be rebuilt then broken down then rebuilt over and over again to keep giving us our energy so that we can do every thing we want to do over and over again

ATP< >ADP ADP< >ATP ATP < >ADP etc…etc…

This reaction takes place trillions and trillions of times every second in all the mitochondria of our cells,and scientists have worked out that every day we make an amount of ATP equal to half our body weight!Yes, that’s right,if you weigh, say, 12 stones then you make 6 stones of ATP every day!

CO enzyme Q10 is found, to a certain extent,in our food, such as in:-

Peanuts, mackerel, herring, sardines (you would have to eat 3 pounds of sardines to get the amount of Co enzyme Q10 in one 100mg capsule!), meat, fish, poultry, kidney, liver, heart, nuts, canola oil, and soybean oil but the majority of Co-enzyme Q10 we make ourselves in our own cells, but especially in our liver.

2000mg is roughly the amount in the average person’s body but after the age 21 liver production starts to diminish, and by the time we reach the age 40 our levels are back to the levels of a 2 year old! So, if you are thinking of maintaining your energy levels in your ageing body then think of taking a supplement of Co enzyme Q10 on a regular basis.

How DID it all start?

As Dennis the Chemist, I have had the honour of meeting two of the three main players involved in the story of Co enzyme Q10. The first was Professor Frederick L. Crane, who is now aged 92. I have met him at several of the world conferences on Co enzyme Q10 over the last 15 years:- Boston, Germany, Italy, London, Prague and Los Angeles. He is the discoverer of Co-enzyme Q10 which happened in 1957.

In 1978, Dr. Peter Mitchell of Glynn Research Laboratories, Bodmin, Cornwall, U.K.received a NOBEL PRIZE for his research on important new aspects of Co enzyme Q10 in mitochondrial energy production.

A few years later in 1986, the late Professor Dr. Karl Folkers (who sadly died age 91 several years ago) was awarded the Priestly Medal from the American Chemical Society for his work with Co-enzyme Q10. He had already been presented a Presidential Certificate of Merit by President Harry Truman in 1948, elected President of the American Chemical Society in 1962, co-recipient of the VanMeter Prize given by the American Thyroid Association in 1969, and in 1990, his numerous merits were rewarded with the President’s National Medal of Science by President George Bush,with the citation:-

“FOR HIS DISCOVERIES AND LEADERSHIP IN COMBINING BASIC CHEMICAL RESEARCH AND CLINICAL MEDICINE TO ACHIEVE NEW TREATMENTS OF DISEASES WHICH HAVE ENHANCED THE QUALITY OF LIFE AND EXTENDED SURVIVAL RATES FOR COUNTLESS PEOPLE”.

It was around this time that, having learnt of the wonders of Co-enzyme Q10 from numerous articles, including the work of Professor Folkers and his work in giving it to cancer patients to help “enhance the quality of life and help to extend survival rates” I started to phone him in America on a regular basis to update him on the progress of patients with cancer who were taking, in addition to their chemotherapy/radiation treatment, Co-enzyme Q10 with another complimentary food substance, the mineral selenium, levels of which, here in the U.K. are the lowest in the world.

He was very pleased with me giving it to so many cancer patients. He said, on the phone, “Dennis, you are my friend, your results show the way Co-enzyme Q10 should be used in high doses (100mg four times day with food). You call me Karl.”

He sent me a signed photograph, which I have in pride of place in my Pharmacy, here in Prestwich, Manchester, England, and which, over the years, thousands of customers/patients have read. It reads:-

“TO DENNIS, THANKING YOU FOR YOUR INITIATIVE AND INSPIRATION IN USING CO ENZYME Q10 and CANCER SIGNED KARL.”

He told me he hoped that there would be enough money generated from interested parties world wide to support very large scale trials to further his research on the use of Co enzyme Q10 in enhancing the quality of life and extending survival rates in cancer patients.We discussed the fact that we thought higher doses would be part of the answer as,15 years ago, when these conversations were taking place, many trials were only using levels of 100mg daily.

Now we know that many people do use much higher levels in different illnesses, and whereas in those days, a dose of 100mg would give a blood level of 2.0 micrograms per ml of blood much higher doses are now given, which culminate in levels as high as 7.0 micrograms per ml of blood. He also felt that many other natural factors would be discovered to enhance the quality of life and extend survival rates, and much research has been ongoing with potential benefits emerging from natural products such as bilberries, pomegranates, alkylglycerols, salvestrols, 1.3/1.6 glucans, plant sterols and sterolin glycosides.

In 1997, the International Co-enzyme Q10 Association was founded by renowned scientists, nutritionalists, and doctors. Kaneka Corporation of Japan, was amongst the founding members.

In 2006 due to rapid growth in consumer consumption in the USA, Kaneka Corporation built the first manufacturing plant in the USA. Kaneka Corporation is the world’s largest manufacturer of Co-enzyme Q10.

What is Red Yeast Rice ?

In China the Taoist tradition dictates colour has symbolic meaning as a sign of prosperity, good fortune and longevity. You will be familiar with Chinese decorations, Peking duck and red gift envelopes.

In the west we colour food using nitrates which you will be familiar with through red salami and sausages. In China, to attain a red colour they use went rice, which is a natural red food colouring. It is available in most Chinese supermarkets in a powder form.

Went rice is a food that is a deep red bordering on crimson. We know it here as red yeast rice. In China it is known as Hong Qu.

How Red Yeast Rice is made?

It is made by culturing the yeast, monascus purpureus, on rice. When performed under sterile and controlled conditions this produces a group of compounds called monacolins that inhibit HMGCoA, a rate limiting reductase enzyme important in cholesterol synthesis.

Under sterile and controlled conditions non-glutinous rice is cooked and then inoculated with a culture of monascus purpureus (a yeast that has a natural red colouring). The rice is then stored for three weeks at 35 degrees centigrade. At the end of the fermentation period the entire batch of rice is now red. The fermentation is stopped by drying the rice. The dried red rice is pulverised in to fine grade powder. This is the end product and can now be used in food or as a food itself. Chinese emperors and courtiers would consume red yeast rice as they believed it prolonged life.

Fast forward in to the twentieth century when Chinese researchers began to investigate what was actually in the red yeast rice that prolonged life. They wanted to find out if it was true. They isolated a group of compounds called monacolins. The monacolins occurred naturally in the dry rice powder in proportions of 0.1%- 3%. Japanese researchers then began investigating the possible action of these fungal isolates.

Eventually they discovered that the  group of compounds called monacolins inhibit HMGCoA, a rate limiting reductase enzyme important in cholesterol synthesis, as well as Q10 steroid hormones and Vitamin D. At the time cholesterol was taking centre stage as a possible target for reducing heart disease and stroke risk. It was theorised that cholesterol was the causative agent of arteriosclerosis, the white hardened plaque that appeared in arteries and heart valves of heart disease patients. It was this plaque that ruptured or broke up and caused a thrombo-embolism in strokes, heart attacks and other vascular events.

If the fungal metabolites, the monocolins, could inhibit cholesterol production and plasma cholesterol levels, then over time would this lead to reduced heart disease in those that consumed it and therefore prolong life? Was this why the Chinese noted its benefits? Over time this monocolin also showed anti-cancer properties in theoretical research.

The researchers were right and soon the statin market was formed. The principle isolate from red yeast rice, monkolin k, was named as lovastatin, the first parent molecule to the rest of the statin family.

Large pharmacetical companies began synthesising lovastatin and selling the drug as an anti-cholesterol cardio-vascular disease modifying agent. Other companies made novel versions. Bayer made a very potent version called cerivastatin that was so strong that a patient suffered bad side effects. The main side effcts of these nerw statins was a muscle weakness and fatigue. In extreme presentations of this strain intolerance rhabdomyolysis, (muscle fibre breakdown) occurred. The end stage of rhabdomyolysis is kidney failure and has a high mortality risk.  Cerivatstain was withdrawn. The search for a potent stain with less side effects continued and several drugs were launched and marketed. Zocor, Lipitor, Liopstat and Crestor. Lipitor atorvatsion became one of the last blockbusters of the 20th century and became the world’s best selling drug.

Quite a journey from a humble yeast. But let us revisit the yeast for a moment. It seems that the yeast is still worth using because it has a low incidence of intolerance. It is easy and cheap to make. It has a long history of use in China.

Many clinical trials have been carried out over the years all over the world. Two human intervention studies (Heber et al., 1999; Lin et al., 2005) investigated the effect of red yeast rice preparations with known monacolin K content on total and LDL-cholesterol concentrations.

Co-enzyme Q10

It is a substance that we all make, it is in every cell in our body, and is involved in practically every single process that takes place in our body. We are made of one hundred trillion cells and each of those cells have little sausage shaped bodies in them called mitochondria. Amazingly we have 500 to 3000 of these mitochondria in every cell! The largest quantities are found in our heart, muscles and our liver as these are some of the most active parts of our body.

It is in these mitochondria that the food that we eat and the oxygen that we breath in are turned into what we call ” our energy”.
This process is similar to the combustion that takes place in the cylinders of our car engines, where the petrol/diesel fuel with oxygen from the air is ignited by the spark from the spark plug to create the energy to propel the car.

Co-enzyme Q10 is our “spark plug”.

The actual” energy” is released from a molecule called Adenosine Triphosphate. Due to the movement of electrons across each mitochondria, called the Oxidative Phosphorylation Pathway, the Co-enzyme Q10 causes the Adenosine Triphosphate (ATP) to break and release a phosphate and become Adenosine Diphosphate (ADP). That explosive break and resultant release of energy is our energy!

Instantly more Co-enzyme Q10 is used to remake the triple phosphate again so that we can keep repeating the process and keep making our energy!

Triple phosphate, double phosphate, triple phosphate, double phosphate over and over again! ATP to ADP, ADP to ATP over and over again, in fact the amount of ATP that we make each day has been calculated to be, by weight, equivalent to half our body weight!

Some of our Co-enzyme Q10 is obtained from our food and is found in peanuts, mackerel, herring, sardines, kidney, liver and heart. Most is made in our body mainly in our liver.

At birth the levels of Co-enzyme Q 10 are quite low but are enough for our needs and by the time we are aged 21 we are making our maximum production of Co-enzyme Q 10 which amounts, at this age, to approximately 2000mg.

As we pass the age 21, production starts to slowly reduce and by the time we are aged 39 to 43 the levels have fallen back to the levels of a two year old! This is are still enough, if we are fit, to live a normal healthy life, both in our work and at leisure.

Ageing further 50, 60, 70, 80 and beyond our production of Co-enzyme Q10 goes lower and lower. We tend to start to realise that, “we haven’t got the energy we use to have”, and that illnesses associated with old age are maybe starting to appear, such as angina, high blood pressure, circulation problems, heart disease, heart failure, muscle strength loss and muscle loss itself (what the doctors call Sarcopenia which, from the Greek, literally means poverty of flesh).

As people  age, many bodily functions can be helped by taking a supplement of Co-enzyme Q10. Over the last 20 years numerous world conferences have taken place at venues including the United Kingdom, USA, Italy, Japan, Belgium, Germany, the Czech Republic and in 2013 the next one will be in Seville in Spain.

Approximately 300 medical specialists from about 90 countries go to each meeting and listen to the latest information about the uses and new uses that have been found in clinical research as to how Co-enzyme Q10 can help peoples’ medical problems.

Topics which are often included are:
The heart, liver, kidneys, circulation, parkinsonism, cancer, chronic fatigue syndrome, age related macular degeneration, pre-eclampsia, down syndrome, high blood pressure, rheumatoid arthritis, angina, muscle loss and muscle strength loss, periodontal (gum) disease, heart attacks, alzheimers disease, muscular dystrophy and helping to lower too high a levels of cholesterol .

The late Professor Doctor Karl Folkers, who received the Perkin Medal in 1960, the Priestley Medal in 1986, and from President Bush, the U.S. medal of Science for defining the structure of Co-enzyme Q 10 and heading up the world research effort for 30 years,has stated:-

“Co-enzyme Q10 is necessary  for human life. Morbidity is associated with a deficiency of Co-enzyme Q 10 of about 75% and death may occur somewhere between deficiency of 75 and 100%.Low tissue deficiencies of Co-enzyme Q 10 may be subclinical but somewhere between 25 and 75% deficiencies, overt disease states may appear”.

Truly then, Co-enzyme Q10 is the “Elixir of Life”.

What is available?

There are two forms of Co-enzyme Q10. It exists as an oxidised form ubiquinone, which is orange, and a reduced form which is white. The reduced form is known as ubiquinol or QH. Due to modern encapsulation and packaging methods the Ubiquinol or uniquinol can be maintained in the reduced form. When buying ubiquinol or reduced co enzyme q10 always make sure it is blister packed in light obscuring outer packaging, both light and air will turn it back in to the less active oxidised orange ubiquinone co enzyme Q10.

I only use and recommend Q10 manufactured by Kaneka. They are leaders in high throughput reverse osmosis membrane technology. Naturally they are Japanese.

What is Moducare?

I often get asked what Moducare actually is? Well, it’s a source of the natural food stuff called sterolin glycosid. Sterolin glycoside are a biology active form sterols and tehy have shown to mainatin a normal immune system which in turn is a healh benefit.  
Please read what professor Pegel says. 

WHAT ARE STEROIDS AND STEROLS: THEIR FUNCTION AND MODE OF ACTION By Prof. Karl H Pegel Steroids including sterols are a family of natural product substances belonging to a vast group of compounds known as terpenoids, all derived biosynthetically from R-mevalonic acid via isopentenol. In animals steroids are derived from the tetracyclic tricterpenoid lanosterol (C30H50O) by its degradation first to cholesterol (C27H46O) which through further metabolic changes gives rise to corticosteroids (C21), sex hormones (pregnanes, C21; androstanes, C19; estranes, C18; vitamin D3, C27; and bile acids, C24). Each class of compound within this steroid family has different structural and functional characteristics. If these compounds were plants, one could consider each class as a genus and each compound within the genus could then be looked on as a species with its own typical bioactive characteristics. Thus the sterol genus, which includes the phytosterols, will have different bioactive characteristics from the corticosteroid genus. There would then be no confusion of bioactive characteristics of species members within the sex hormone genus with bioactivities of species members within the corticosteroid genus. The structural and functional differences between species of the sterol genus and species of the corticosteroid genus are more pronounced than the differences between some of the sex hormones and the corticosteroids and it is therefore not surprising that there are vast bioactivity differences between sterols and corticosteroids as well as the sex hormones. There is also no obvious reason why cholesterol and its sterol genus plant analogue sitosterol should have corticosteroid or sex hormone type of activity. Cholesterol in animals and sitosterol in plants have two important functions of which the more prominent is their use as essential static components in cell membranes regulating their permeability and membrane associated enzyme activities. If the sterol concentration is too high in cellular membranes then their permeability and associated enzyme activities are impaired in both plants and in animals. In animals a small amount of sitosterol counteracts the cholesterol condensing effect on membranes, while in plants cholesterol counteracts the sitosterol condensing effect. Secondly, cholesterol serves as a precursor for the various steroid genera such as the corticosteroids, sex hormones, bile acids, and vitamin D3.

The production of these compounds is on demand and usually self-regulating. Sitosteryl glucoside (a sterolin) is an important primary metabolite in plants although its function in plants is as yet unknown. It has however been shown that it promotes cell membrane permeability and hence absorption or passage of proteins through cell membranes. All steryl glucosides have this ability although sitosterolin is more effective than cholesterolin. Cholesterolin is also synthesized in animals under certain stress conditions and can therefore be considered as an anti-stress agent since it induces the formation of beneficial ‘heat-shock proteins’. 

Moducare™ contains both sitosterol and sitosterolin. By their inherent nature as ‘static’ cell membrane components they counteract any deleterious permeability cell membrane effects and associated impaired enzyme activities both vital for keeping the various immune system components in balance and under feedback control. Steroid hormones on the other hand act as ‘mobile’ messenger molecules by first binding to specific receptor proteins inside the cell before these complexes bind to specific sites on DNA thereby inducing the formation of new mRNAs and new proteins. Thus the mode of action of sitosterol/sitosterolin and the steroid hormones is different. The first act as beneficial ‘static’ membrane components thereby maintaining an effective permeability and associated enzyme activity resulting in a regulated environment within the cell. The various steroid hormones, on the other hand, are ‘mobile’ messengers controlling the induction or repression of specific sets of genes resulting in rather distinct modes of cellular responses which may be helpful to control a disease condition, but will not necessarily be beneficial in the long run. The lowering of the mainly Th2 related IL-6 observed for corticosteroids and Moducare‘ is therefore due to different modes of action.

In the case of corticosteroids this is probably achieved by a general suppression of the Th1/Th2 immune system, while sitosterol/sitosterolin achieves this by a regulatory mode causing minimum disruption of immune functions. An interesting recent application of sitosterol is its use of its hydrogenated and esterified forms, sitostanyl ester, incorporated into margarines and other food products to lower elevated serum cholesterol levels. Sitostanol does this by most, but not all, accounts more efficiently than sitosterol or its esters. At the same time sitostanol also lowers serum sitosterol levels more efficiently than cholesterol levels with the result that serum sitosterol:cholesterol ratios are reduced. This suggests, in the light of the above explanations, that a prolonged consumption of sitostanol food products (so-called neutraceuticals) may have serious health consequences. Only one study so far has reported the development of prostatitis in male subject towards the end of a four-week trial period. This is rather ironic when one considers that sitosterol/sitosterolin products are used in Germany to treat benign prostate hypertrophy.

Maitake D-Fraction:

Maitake D-Fraction: Apoptosis Inducer and Immune Enhancer By Sensuke Konno, Ph.D

(This information is taken from Excerpts from Dr. Konno’s Article on Maitake D- Fraction published in Alternative & Complementary Therapies, April 2001)

Maitake, The King of Mushrooms

Maitake is indigenous to Northern Japan. For hundreds of years, this rare and tasty mushroom has been praised by traditional Japanese herbalists. Maitake literally means, “dancing mushroom.” 8 Maitake is a giant mushroom that often reaches 20 inches in diameter an that may weigh up to 100 pounds. Such unique characteristics and potential health benefits are why it is often considered the “king of the mushrooms.” Maitake is still one of the most valuable an expensive mushrooms in Japan today.

Maitake mushroom has been available via cultivation since the mid-1980’s, enabling mycologist and pharmacologists to study the medicinal properties that have been claimed in anecdotes and folklore regarding this mushroom. Numerous physiologic benefits of maitake have been postulated, ranging from antitumor, effects to treatment for hypertension, diabetes, hypercholesterolemia, obesity and hepatitis B infection. 3-7,9-12

Maitake’s antiviral activity against human immunodeficiency virus (HIV)/auto- immune deficiency syndrome (AIDS) was confirmed by the U.S. National Cancer Institute in 1992.

Maitake D-Fraction

Most research on maitake has been focused on the use of maitake D-fraction for treatment of various malignancies. The bioactive D-fraction that is extracted from maitake is the protein-bound polysaccharide compound and is prepared by a standardized procedure developed by Maitake Products, Inc. (Ridgefield, New Jersey). Among the various maitake fractions that have been prepared, D- fraction was found to be the most potent for enhancing the immune system via oral administration or injection, (effective regardless of route of administration) leading to the highest reduction rate in cancer proliferation. 14-16

D-fraction as an Immune Booster

Maitake D-fraction has been shown to have an antitumor effect on tumor-bearing mice, 14 with enhanced cytotoxic activity of macrophages and elevated production of interleukin-1 leading to the activation of cytotoxic T-lymphocytes (CTSs). 17. These findings are highly suggestive that D-fraction acts not only via direct activation of various immune effectors (macrophages, CTLs, natural -killer (NK) cells, etc) targeting tumor cells but also via potentiating the activity/production of various lymphokines. Thus D-fraction appears to have a potent immunostimulatory activity, which may account primarily for its anti-tumor effect on cancer cells.

D-Fraction as an Apoptosis Inducer- Prostate Cancer

Prostate cancer is the most common malignance with high mortality in elderly men in the United States. In 1999, cancer statistics noted that approximately 140,000 new cases and more than 39,000 deaths were expected to occur annually. 19

“Because of the total failure of chemotherapy treatment of prostate cancer, an improved efficacy of chemotherapy is urgently required.” 22

This high mortality is attributable primarily to disease progression to a hormone- refractory or androgen-independent cancer state. …Unfortunately current conventional therapies for hormone-refractory prostate cancer are ineffective. 22

Androgen ablation, brachytherapy (radioactive seeds implanting), and chemotherapy are viable therapeutic options but have not been able to achieve the expected level of efficacy.

To explore a more effective modality for treatment of prostate cancer, a research group from the Department of Urology at New York Medical College (Valhalla, New York), has recently conducted a study on the ability of maitake D-fraction to induce apoptosis activity against human prostatic cancer PC-3 cells (the most aggressive and metastatic cancer cells) in vitro. 23

Experiments were performed, including a dose-response study and examinations of potentiation with Vitamin C and chemosensitizing effect on anticancer drugs.

The Results:

Potent Apoptosis-Inducing Activity

When PC-3 cells were treated with D-fraction at a concentration of 480 ug/ml, almost complete cell death (>95%) was observed in 24 hours, accompanied by “cell blebbing” (vesicle formation) and considerable damage in the plasma membrane assessed by lipid peroxidation assay. These cellular alterations are indicative of oxidative stress (generation of oxygen free radicals), which appears to subsequently to cause discrete DNA fragmentation in cancer cells. Histologic (in situ hybridization) and molecular analysis then confirmed that cell death induced by D-fraction had resulted most likely from apoptosis suggesting that the D-fraction is a potential apoptosis inducer.

Synergy with Vitamin C

As little as 30-60 ug/mL (one sixteenth to on eighth of 480 ug/mL) of D-fraction combined with 200uM of vitamin C was found to b e nearly as effective as 480 ug/mL of D-fraction alone, resulting in a >95% cell death. It has been reported anecdotally by a number of doctors and patients that D-fraction appeared to work very well (cooperatively) with vitamin C. Such synergy has now been evidenced in this study.

Chemosensitizing Effect

It was of additional interest to explore a possible chemosensitizing effect of D- fraction on anticancer drugs that are currently in use. Because of the total failure of chemotherapy in the treatment of prostate cancer, 22, an improved efficacy of chemotherapy is urgently required. Compared to approximately a 50% reduction in cell viability induced by carmustine (a common Chemotherapeutic agent used in brain tumor treatment) alone, approximately a 90% reduction in viability was attained when 60 ug.mL of D-fraction was combined with carmustine. This study implies that D-fraction may also have a chemosensitizing activity on certain anticancer drugs, helping to improve the efficacy of chemotherapy.

D-Fraction as a Metastasis Inhibitor

Inhibition of cancer metastasis is another critical issue in the slowing down of cancer progression or prolonging the survival time. This aspect of cancer treatment was addressed in a 1995 study of maitake D-fraction.25 The results suggest that maitake preparations are capable of preventing tumor metastasis, presumably by necrotizing tumor cells present in the blood and /or lymphatic vessels via the activated immune-competent cells.

Clinical Trials in Human Subjects

Although a number of animal studies have confirmed maitake’s ability to inhibit cancer, not many human trials have yet been conducted. To test whether the efficacy of D-fraction demonstrated on animals 14,15 could be verified in patients with cancer, a non-randomized clinical study was conducted on 165 patients (25- 65 years old) with various types of advanced cancers. The results showed that tumor regression or significant symptomatic improvements with D-fraction were observed in 73% of patients with breast cancer, 67% of patients with lung cancer, and 47% of patients with liver cancer. When D-fraction was given with chemotherapy, the response rates improved from 12% to 28%.

Overall, the following trends were found: the clinical status of patients with breast, prostate, lung, and liver cancers was improved significantly with D- fraction, while the D-fraction was less effective on subjects with bone and stomach cancers or with leukemia.

It is important to note that many side effects of chemotherapy on all patients with all types of cancers were ameliorated when D-fraction was given with conventional treatment. Adverse symptoms, such as nausea, hair loss, and leukopenia, were alleviated in 90% of the patients in the study. A reduction in pain was also reported in 83% of the study patients.

Based on the above studies and the in vitro prostate cancer study, it is conceivable that maitake D-fraction may work cooperatively with chemotherapy, implying that D-fraction should be considered as a valuable adjuvant in ongoing cancer chemotherapy.

Effects of D-fraction on HIV/AIDS and Kaposi’s Sarcoma

Both the National Institute of Health in Japan (Tokyo) and the U.S. National Cancer Institute (Bethesda, Maryland) have confirmed that maitake D-Fraction was able to prevent the HIV-mediated destruction of T-helper lymphocytes up to 97% in vitro.13

These findings suggest that D-fraction may even help to prevent of slow down the progression of HIV to full-blown AIDS. Several physicians who used D- fraction for the treatment of patients with HIV/AIDS have also reported that oral administration of D-fraction had significantly improved the clinical conditions of patients with Kaposi’s sarcoma (even those who were undergoing radiotherapy and other AIDS-related symptoms. 26

Toxicity

The FDA has exempted D-fraction from a phase I study of toxicology. Maitake D-fraction (liquid form) and maitake tablets (whole crude powder) were tested on mice to assess potential toxicity. 18

Based on a pilot study indication the optimal dose of 1 mg/kg of D-fraction for antitumor activity, a ten-times-higher dosage was given to mice for 30 days. On the thirty-first day, no abnormal symptoms or signs were observed when mice were killed and their organs and blood thoroughly examined.

Similar tests were repeated using maitake tablets and essentially the same results as the D-fraction tests were obtained with no toxic or adverse effects. The researchers concluded that both maitake D-fraction and tablets are safe with no toxicity. Indeed, such safety is supported further by the fact that the FDA has exempted D-fraction from a phase I study of toxicology. 26

FDA Approval of the IND for D-fraction for Breast and Prostate Cancers

In 1998, the Food and Drug Administration (FDA) granted Maitake Products, IN (Paramus, New Jersey), an investigational new drug application (IND) to conduct a phase II pilot study using maitake D-fraction on patients with advanced breast and prostate cancers. These studies are currently underway at Metabolic Associates (Florham Park, New Jersey) to evaluate the immune stimulatory effect of D-fraction on tumor size, tumor makers, immune assays, clinical symptoms, and quality of life of patients. Other independent institutions are also planning to conduct similar trials.

Recommended Maitake Dosage

Fukumi Morishige, M.D., Ph.D, a renowned Japanese surgeon and a member of the Linus Pauling Institute, Corvallis, Oregon, explains that taking small amounts of vitamin C along with the mushroom supplements will facilitate absorption of polysaccharides and enhance their effectiveness further.27. Such increased absorption renders polysaccharides more accessible to immune cells, including macrophages and NK cells. As, mentioned earlier, the synergy with vitamin C was also demonstrated by the study on maitake D-fraction-induced apoptosis in prostate cancer PC-3 cells. 29

The following dosages of maitake D-fraction and maitake tablets for adults are recommended. (but not established)

• 1-4 per day of maitake tablets for prevention and 4-7 grams for therapeutic self- help. (e.g. for patients with chronic immune dysfunction).

• 5-6 drops of maitake D-fraction (GrifronPro D-fraction®; Maitake Products, Inc.) 3 times per day, for health maintenance and 15-20 drops, 3 times per day for therapeutic purposes.

• Optionally, 250-1000 mg of Vitamin C can be taken with maitake D-fraction or tablets as described above.

Note: Please, consult your physician/healthcare professional as to what dosage you should be taking for your condition. To learn more about this natural healing agent, see Maitake.com.

References

3.Mizuno,T. et al. Maitake, Grifola frondosa; Pharmacological effects. Food Rev. Int. 11:135-149, 1995.

4. Preuss, H. et al. Syndrome X, hypertension, and maitake mushroom. Int I Integrative Med. 1:42, 1999.

5. Kubo, K., et al. Anti-diabetic activity present in the fruit body of Grifola frondosa )maitake). Biol Pharm Bull 17:1106-1110, 1994.

6. Kubo, K., Nanba, H. The effect of maitake mushrooms on liver and serum lipids. Altern Ther Health Med.2:62-66, 1966.

7. Jones, K. Maitake: A potent medicinal food. Alternative & Complimentary Therapies 4:420-429, 1998.

8. Lieberman, S, et al. Maitake, King of Mushrooms: A Keats Good Health Guide. New Caanan, CT: Keats Publishing, 1997.

9. Kabir, Y., et al. Effect of shiitake and maitake mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. I Nutr Sci 33:341-346, 1987.

10. Adachi, K., et al. Blood pressure lowering activity present in the fruit body of Grifola frondosa. Chem Pharm Bull 36:1000-1006, 1988.

11. Nakai, R. et al. Effect of maitake (Grifola frondosa) water extract on inhibition of adipocyte conversion of C3H10T1/2B2C1 cells. I Nutr Sci Vitaminol (Toyko) 45:385-389, 1999.

12. Wu, S., et al. Therapeutic effect of Grifola Polysaccharides in Chronic hepatitis B (abstr.I. International Programme and Abstracts. International Symposium on Production and Products of Lentinus Mushroom, Quingyan, Zhejiang, China, November, 1-3, 1994.

13. Developemental Therapeutics Program, National Cancer Institute. In-vitro anti-HIV drug screening results. NSC: F195001, Jan. 1992.

14. Hishida, I., et al. Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake). Chem Pharm Bull, 36:1819-1827, 1988.

15. Nanba, H. Antitumor activity of orally administered D-fraction from maitake mushroom, I Naturopathic Med. 1:10-15, 1993.

16. Ohno, N., et al. Structural characterization and antitumor activity of the extracts from matted mycelium of cultured Grifola frondosa. Chem Pharm Bull 33:3395-3401, 1985.

17. Adachi, K., et al. Potentiation of host-mediated antitumor activity in mice by B-glutan obtained from Grifola frondosa (maitake). Chem Pharm Bull 35:262-270, 1987.

18. Nanba, H. Maitake D-fraction: Healing and preventive potential for cancer. I Orthomol Med 12:43-49, 1997.

19. Landis, S.H., et al. Cancer statistics, 1999. CA Cancer I Clin 49:8-31, 1999.

20. Mahler, C., et al. Management of relapsing disease in prostate cancer. Cancer 70:329-334, 1992.

21. Davis, P., et al. Regulation of prostate growth. I Endocrinol 131:5-17, 1991.

22. Kreis, W. Current chemotherapy and future directions in research for the treatment of advanced hormone-refractory prostate cancer. Cancer Invest 13:296-321, 1995.

23. Borchers, A.T., et al. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med 221:281-293, 1999.

24. Berges, R., et al. Programming events in the regulation of cell proliferation and dealth. Clin Chem 39:356-361., 1993.

26. Maitake D-fraction obtained IND for clinical study (corporation publication). Paramus, NJ; Maitake Products, Inc., Feb. 1998.

27. Morishige, F. The role of vitamin C in tumor therapy (human). IN: Meyskens, F.I. Jr. , Parasad, K.N. (eds). Vitamins and Cancer; Human Cancer Prevention by Vitamins and Micronutrients. Clifton, NJ; Humana Press, 1986. pp. 399-427.

29. Guidance for Grifron products for health professionals (corporation publication). Paramus, NJ; Maitake Products, Inc., 1997.

Magnesium therapy: could it be the answer to migraine relief?

Magnesium therapy: could it be the answer to migraine relief?

Turning to magnesium to aid with restless legs, Barnaby was delighted that the mineral helped in another life-changing way

Having suffered with restless legs and migraines for as long as he can remember, 15-year-old Barnaby Albiston, from South London, has shared his secret to relief from life-long discomfort – by boosting his magnesium levels.

Barnaby’s mum, Diana Albiston, said: “Barnaby has suffered with restless legs for most of his life, even as a baby when he slept in a sleeping bag (which is meant to be the safest sleeping option) his active legs would lift up and over, and the whole sleeping bag would cover his face.

“Getting to sleep has always been the main problem, Barnaby just has the urge to move his legs all the time. We tried tiring him out during the day, various relaxation techniques such as massaging lavender scented lotion into his legs and buying short pyjamas as well as a lighter duvet – but nothing helped.”

After reading an article in the newspaper recounting how magnesium may help with restless legs and that the best way to administer it is externally, through the skin, Diana purchased BetterYou’s Magnesium Sensitive Body Spray, followed by the Magnesium Oil Body Spray.

“We had never used magnesium products before, so we started with the sensitive spray. It is easy to apply and rub in and Barnaby’s not at all bothered about having oil on his legs, but it soaks in quickly anyway.

“Since using the spray, Barnaby has been able to resist the temptation to move his legs in bed and while we bought the spray to help with restless legs, we didn’t expect the positive impact it had on Barnaby’s migraines”, says Diana.

“I first recognised Barnaby was experiencing migraines when he was five years old, but I think they started much younger. Due to the sickness that accompanied the migraines, I just thought he had picked up bugs and it was difficult for him to tell me how he was feeling, because he is profoundly deaf and didn’t start speaking until much later in life.

“It was only when the migraines started following a pattern that Barnaby was able to tell me what he was experiencing. They don’t always present themselves in the same way, but symptoms can include extreme tiredness, nausea or sickness, fluctuation of temperature and sensitivity to light.

“We try to avoid migraines starting and have begun to recognise some of the triggers for Barnaby including; disturbed or lack of sleep, keeping away from flashing lights and no long and tiring days out, as well as minimising distance to travel and not socialising with large groups of people”, Diana continues. 

“Two weeks after we started applying the magnesium spray to Barnaby’s legs, it hit us that he hadn’t had a migraine in that time. We have now been using the spray for just over two years and Barnaby’s migraines have dropped from two a week, to one every two months.

“The considerable decrease in Barnaby’s migraine episodes means that we can afford to make plans more confidently, rather than thinking in the back of our minds that any plans we make are likely to be cut-short or cancelled.

“We would definitely recommend BetterYou’s magnesium body sprays, we like the fact that they are easy to apply and there is no smell at all. As Barnaby now relates the smell of lavender with ‘trying to get to sleep’, it seems to have an adverse effect, so unscented products are ideal for us”, concludes Diana.

Clinical studies have shown that migraineurs have low brain magnesium during migraine attacks and may also suffer from magnesium deficiency.

Low levels of this powerful mineral are estimated to affect around 70 per cent of people, so it’s important to find ways to increase levels within the body and supplementing can help.

Magnesium is a mineral that is difficult to supplement through traditional oral means, such as tablets and capsules. As it is a natural relaxant, too much can have a laxative effect.

Studies have shown that supplementing magnesium transdermally (through the skin), provides a highly effective and convenient method of elevating magnesium levels within the body. Applied directly to the skin, absorption of magnesium commences immediately, helping to promote natural relaxation.

https://www.dennisthechemist.com/betteryou-magnesium-flakes-1kg-p551513.html

https://www.dennisthechemist.com/betteryou-magnesium-sleep-mineral-lotion-180ml-p549012.html

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Why should you take MSM ?

MSM BACKGROUND

MSM stands for Methyl-Sulfonyl-methane (Dimethyl Sulfone). This is a nonmetaliic sulphur compound which widely occurs in nature. Sulfur is a yellow material which has a number of large physical forms, crystalline as well as liquid. It is one of the most common substances found in the body. Sulfur plays an important role in human nutrition, a fact commonly overlooked.

MSM is a derivative of DMSO (dimethyl-sulfoxide). DMSO is widely used to treat animals such as horses to reduce inflammation in joints and injured areas. The side effects of smells and impurities limit the widespread use of DMSO in humans.

MSM is a white, odourless crystalline material resembling sugar. The sulphur component of MSM is 34%, by weight, making MSM one of nature’s richest sources of sulphur. MSM tastes slightly bitter and mixes easily into water or juice as the solubility of MSM is very high. MSM is as basic to life as water and salt. It is completely non-toxic – as safe as water!

MSM belongs in the same chemical family which includes oxygen. For organisms living in an environment without oxygen, sulphur often replaces oxygen as the source of chemical energy that drives life!

WHY DO WE NEED SULFUR?

Sulfur is found naturally in the human body. Sulfur is stored in every cell of the body. The highest concentrations are found in the joints, hair, skin, and nails. Excess sulphur is excreted in the urine (about four to 11 mg. MSM pre day) and the faeces. Available in 300g tubs https://www.dennisthechemist.com/dennisthechemist-msm-flakes-300g-p525328.html